These letters were assembled by Lady Paget as a collection of autographs. Most are addressed to Paget, and their subjects include medicine, science, and family.

These letters, most of which are undated, concern natural history, spiritualism, his publications, lectures, and teaching.

The collection is a miscellaneous group of letters of mainly British scientists and physicians, purchased as an existing autograph collection. There are a few American signatures. The letters are primarily from the nineteenth century and focus on medical and geological topics, but also there are some earlier and later dates. In addition to the letters are anatomical drawings of surgery, sketches of bones, and one geological notebook.